研究業績

（学術論文）

（原著）

 

1.Yoshimoto M, Tokuda A, Nishiwaki K, Sengoku K, Yaginuma Y.

   Abnormal Expression of PICT-1 and its Codon389 Polymorphism is a Risk Factor for Human Endometrial Cancer

   Oncology 95,43-51.2018

​

2.Yaginuma Y, Yoshimoto M, Tokuda A.

   USP15 inhibits HPV16 E6 degradation and catalytically inactive USP15 has reduced inhibitory activity

   Acta. Virol. 62(2),147-156.2018

 

3.Yoshimoto M, Tokuda A, Nishiwaki K, Sengoku K, Yaginuma Y.

   The protein interacting with carboxyl terminus-1 codon 389 polymorphism impairs protein interacting with carboxyl    

   terminus-1  function and is a risk factor for uterine cervical cancer

   Mol Carcinog. 56(5), 1484-1492, 2017

 

4.Yuji Yaginuma, Masafumi Yoshimoto, Ayami Eguchi, Aoi Tokuda, Shoko Takahashi.

   The human papillomavirus 18 E7 protein inhibits CENP-C binding to α-satellite DNA

   Virus Research 205,27-32.2015

 

5.Yuji Yaginuma, Ayami Eguchi, and Masafumi Yoshimoto.

   HPVs and Kinetochore Functions in Cervical Cancers

   JSM Clin Oncol Res 2(2),1011.2014

 

6.Yaginuma,Y., Eguchi,A., Yoshimoto, M., Ogawa,K.

   The PxDLLCxE Sequence in Conserved Region2 of Human Papilloma Virus 18 Protein E7 is Required Binding to Centromere  

   Protein C

   Oncology 83,210-217.2012

 

7.Yaginuma,Y., Yoda,K., Ogawa,K.

   Characterization of Physical Binding between Human Papillomavirus 18 Protein E7 and Centromere Protein C

   Oncology 79,219-228.2010

 

8.Imai, K., Yamamoto, M., Tanaka, H., Hashimoto, N., Miyakoshi, M., Honmou, S., Yoshie, M.,

   Tamakawa, S., Yaginuma, Y., Kasai, S., Ogawa, K.

　 Low selection of preneoplastic hepatocytes after treatment with the 2-acetylaminofluorene

    diet-partial hepatectomy regimen in the liver of hepatocarcinogenesis-resistant DRH strain rats.

    Oncol Rep 17, 55-60. 2007

 

9.Tanaka, H., Yamamoto, M., Hashimoto, N., Miyakoshi, M., Tamakawa, S., Yoshie, M., Tokusashi, Y.,

    Yokoyama, K., Yaginuma, Y.,Ogawa, K.

　 Hypoxia-independent overexpression of hypoxia-inducible factor 1alpha as an early change in mouse

    hepatocarcinogenesis.

　 Cancer Res 66, 11263-11270. 2006

 

10.Asai, K., Tamakawa, S., Yamamoto, M., Yoshie, M., Tokusashi, Y., Yaginuma, Y., Kasai, S.,

     and Ogawa, K.

     Activated hepatic stellate cells overexpress p75NTR after partial hepatectomy and undergo apoptosis

     on nerve growth  factor stimulation.

     Liver Int 26, 595-603. 2006

 

11. Yamamoto, M., Tamakawa, S., Yoshie, M., Yaginuma, Y., and Ogawa, K.

　   Neoplastic hepatocyte growth associated with cyclin D1 redistribution from the cytoplasm to the

      nucleus in mouse hepatocarcinogenesis.

      Mol Carcinog 45, 901-913. 2006

 

12. Imamura, E., Yamamoto, M., Miyakoshi, M., Honmo, S., Ozaki, A., Yoshie, M., Tamakawa, S.,

      Yaginuma, Y., Kasai, S., Ogawa, K.

      Different growth capacity between infant and adult mouse hepatocytes in vitro correlates to the

      cyclin D level without relation to oxidative DNA damage. 

      Liver Int.　 25,1036-1043 2005

 

13. Tokusashi, Y., Asai, K., Tamadawa, S., Yamamoto, M., Yoshie, M., Yaginuma, Y., Miyokawa,

      N., Aoki, T., Kino, S., Kasai, S., Ogawa, K.

      Expression of NGF in hepatocellular carcinoma cells with its receptors in non-tumor cell components.

      Int. J. Cancer 114:39-45 2005

 

14. Ogawa, K., Yoshie, M., Tamakawa, S., Tokusashi, Y., Yamamoto, M., Yaginuma, Y.

      Possible role of the microenvironment created by neoplastic hepatocytes during carcinogenesis. 

      Appl. Genom. Proeom. 2:135-143 2003

 

15. Ishizaki, T., Yoshie, M., Yaginuma, Y., Tanaka, T., and Ogawa, K 

     Loss of Igf2 imprinting in monoclonal mouse hepatic tumor cells is not associated with abnormal

     methylation patterns for the H19, Igf2 and Kvlqt1 differentially-methylated regions.

     Journal of Biological Chemistry 278,6222-6228 2003

 

16.Yuichi Sato, Motoko Takahashi, Yukinao Shibukawa, Suresh K.Jain, Reiko Hamaoka,

     Junichiro Miyagawa, Yuji Yaginuma, Koichi Honke, Mutsuo Ishikawa, and Naoyuki Taniguchi 

     Overexpression of N-Acetylglucosaminyltransferase III Enhances the Epidermal Growth

     Factor-induced Phosphorylation of ERK in HeLaS3 Cells by Up-regulation of the Internationalization

     Rate of the Receptors.

     Journal of Biological Chemistry 276,11956-11962 2001

 

17. Tomoaki Takahashi, Yoshitaka Ikeda, Eiji Miyoshi, Yuji Yaginuma, Mutsuo Ishikawa, Naoyuki Taniguchi .   alpha1,6    

     Fucosyltransferase is highly and specifically 　expressed in human ovarian

     serous　adenocarcinomas. 

     Int. J. Cancer 88,914-919 2000

 

18.Yaginuma Y, Yamashita T, Ishiya T, Morizaki A, Katoh Y, Takahashi T, Hayashi H, Ishikawa M.

     Abnormal structure and expression of PTEN/MMAC1 gene in human uterine cancers.

     Mol Carcinog. 27(2),110-116 2000

 

19.Hayashi H, Yaginuma Y, Yamashita T, Morizaki A, Ishiya T, Katou Y, Ishikawa M.

     Prospective randomized study of antibiotic prophylaxis for nonlaparotomy surgery in

     benign conditions.

     Chemotherapy 46(3),213-218 2000

 

20. Tsuyoshi Yamashita, Yuji Yaginuma, Yuji Saitoh, Kiitirou Kawai, Toshiyuki Kurakane,

     Hiroaki Hayashi, Mutsuo Ishikawa

     Codon 72 polymorphism of p53 as a risk factor for patients with human

     papillomavirus-associated squamous intraepithelial lesions and invasive cancer of the

     uterine cervix.

     Carcinogenesis 20(9),1733-1736 1999

 

21. Saitoh Y., Yaginuma Y., Ishikawa M.

     Analysis of Bcl-2, Bax and Survivin genes in uterine cancer.

     Int J Oncol . 15(1),137-141 1999

 

22. Hamaoka R, Yaginuma Y, Takahashi T, Fujii J, Koizumi M, Seu HG, Hatanaka Y, Hashizume K,

     Ii K, Miyagawa J, Hanafusa T, Matsuzawa Y, Ishikawa M and Taniguchi N.

     Differential expression patterns of nitric oxide synthase isozymes in various

     gynecological cancers.

     J Cancer Res Clin Oncol. 125(6),321-326 1999

 

23.Hiroaki Hayashi, Yuji Yaginuma, Shinitsu Kitamura, Yuji Saitoh, Toshinobu Miyamoto,

     Harumi Komori, Keiko Wada, and Mutsuo Ishikawa.

     Bilateral oophorectomy in asymptomatic women over 50 years old selected by ovarian cancer screening.

     Gynecologic and Obstetric Investigation 47,58-64 1999

 

22.K.Kawai, Y.Yaginuma, H.Tsuruoka, M.Griffin, H.Hayashi, and M.Ishikawa 

    Telomerase Activity and Human Papillomavirus (HPV) Infection in Human Uterine Cervical Cancers

    and Cervical Smears.

    European Journal of Cancer. 34(13),2082-2086 1998

 

24.Toshinobu  Miyamoto, Yoshihiro  Jinno, Kiyonori,  Miura, Kazuo Sengoku, Hidenobu  Soejima,

    Kankatsu Yun, Yuji Yaginuma, Norio Niikawa,Mutsuo Ishikawa   

    A  SacII polymorphism in the human.

 

25.Yuji Yaginuma, Kunihiko Nishiwaki, Shinitsu Kitamura, Hiroaki Hayashi, Kazuo Sengoku,

    Mutsuo Ishikawa 

    Relaxation of insulin-like growth factor-II gene imprinting in human gynecologic tumors.

    Oncology.54,502-507 1997

 

26.Yuji Yaginuma, Hiroaki Hayashi, Kiitirou Kawai, Toshiyuki Kurakane, Yuji Saitoh, Sinitu Kitamura,

    Kazuo Sengoku, Mutsuo Ishikawa.

    Analysis of the Rb gene and cyclin-dependent kinase 4 inhibitor genes(p16ink4 and p15ink4b) in

    human ovarian carcinoma cell lines. 

    Expereimental Cell Research 233,233-239 1997

 

27.Yaginuma,Y., Ishikawa,M.

    Gene therapy by p53 gene.   

    Oncology and Chemotherapy 13(4) 1997

 

28.Tsuyoshi Yamashita, Yuji Yaginuma, Kohki Yamashita, Masahiro Fujita, Mutsuo Ishikawa.

    DCC gene alterations in histological types and clinical stages of epithelial ovarian cancer.

    International Journal of Oncology.9  1996

 

29.Yaginuma,Y., Katayama,H., Kawai,K., Duenas,J-C.,Ishikawa,M.

    Analysis of the retinoblastoma gene in human endometrial carcinoma. 

    Obstet. Gynecol 87,755-759 1996

 

30.Yaginuma,Y.,Yamashita,T., Takuma,N., Katayama,H.,Ishikawa,M.

     Analysis of the p53 gene in human choriocarcinoma cell lines.   

     Br.J.Cancer. 71,9-12  1995

 

31. Yaginuma,Y., Fujita, M., Saitoh,S., Hayakawa,K., Kuzumaki,N., Ishikawa,M.

      Immunohistochemical analysis of ras p21 oncogene product p21 in human endometrial carcinoma.

      Acta histochem 95,23-29  1993

 

 

32. Ishikawa,M., Nakata,T., Yaginuma,Y., Nishiwaki,K., Goishi,K., Saitoh,S.

     Expression of superoxide dismutase (SOD) in adenomyosis.

     Am J Obstet.Gynecol. 169 (3)、730-734 1993

 

33. Yaginuma,Y., Westphal,H. 

     Abnormal structure and expression of the p53 gene in human ovarian carcinoma cell lines. 

     Cancer Res.52 (15),4196-4199  1992

 

34. Yaginuma,Y., Yamashita,K., Kuzumaki,N., Fujita,M., and Shimizu.T.

      Ras oncogene product p21 expression and prognosis of human ovarian tumors. 

      Gynecol Oncol.46,45-50  1992

 

35. Yaginuma, Y., Westphal, H.

      Analysis of the p53 gene in human uterine carcinoma cell lines. 

      Cancer Res. 51(24),6506-6509 1991

 

36. Ishikawa,M., Yaginuma,Y., Hayashi,H., Shimizu,T.,  Endoh,Y., and Taniguchi,N.

     Reactivity of a monoclonal antibody to manganese superoxide dismutase.

     Cancer Res.50 (8),2538-2542  1990

 

(症例報告)（欧文）

1. Miyamoto T, Hayashi H, Sengoku K, Ojima H, Tokusashi Y, Yaginuma Y, Takuma N, Hasuike S,

    Miyokawa N, Ishikawa M.

    Diffuse malignant mesothelioma of the uterus.

    Acta Obstet Gynecol Scand. 79(2) 2000

 

2.Yuji Yaginuma, Mitsuhiro Kawamura, and Mutsuo Ishikawa.

   Landry-Guillain-Barre-Strohl Syndrome in Pregnancy.

   J.Obstet.  Gynaecol. Res. 22(1),47-49 1996

 

3.Yuji Yaginuma, Mitsuhiro Kawamura, and Mutsuo Ishikawa.

   Pregnancy, Labor and Delivery in a Woman with a Damaged Spinal Cord.

   J.Obstet. Gynaecol. Res. 21(3),277-279 1995

 

(総説)（和文）

1.吉本賢史、徳田葵、柳沼裕二

   卵巣癌の発癌と起源

　熊本大学医学部保健学科紀要 14:22-32 2018

​

​

2.徳田葵、吉本賢史、柳沼裕二

   子宮内膜症関連卵巣腫瘍の発生機序

　熊本大学医学部保健学科紀要 14:11-21 2018

 

 

3.吉本賢史、江口礼好、柳沼裕二

　子宮体癌の分子生物学的発生機序

　熊本大学医学部保健学科紀要 11:1-1２ 2015

 

 

4.吉本賢史、江口礼好、柳沼裕二

   悪性卵巣腫瘍の分子生物学的発生機序

　熊本大学医学部保健学科紀要　10:1-1４ 2014

　

5. Ogawa, K., Yaginuma, Y.

    b-catenin 

    Nippon Rinsho 59 2001

 

6. 石川睦男、柳沼裕二  

    HPVと子宮頚癌 

    臨床医 22(9):2149-2151 1997

 

7. 石川睦男、柳沼裕二  

    SLE 

    臨床婦人科産科 50(6):774-776 1996

 

8. 石川睦男、柳沼裕二　

   クラミジア感染症

　産婦人科の実際 44(11):1581-1585 1995

 

9. Yaginuma,Y., Yamashita,T., Duenas,J.C., Katayama,H., and Ishikawa,M.  

   Analysis of p53 gene in gynecologic tumors.

   Jpn J Clin Pathol. 42:235-241 1994

 

（著書）

1. 産科婦人科学 1999  へるす出版監修：加藤宏一 分担執筆　柳沼裕二　

　「先天異常のスクリーニング」の項目を執筆

 

2. 更年期医療 1996  医薬ジャーナル社編集：石川睦男、玉舎輝彦 分担執筆　柳沼裕二　

　「性機能障害」の項目を執筆

 

3.ＳＯＤの新知見（構造、機能と診断、治療へのかかわり）　1990　 メジカルビュー社　

　　編集：勝部幸輝、谷口直之

　　分担執筆：卵巣腫瘍におけるMnSOD測定の意義

　　石川睦男、柳沼裕二、林博章、清水哲也、山下幸紀、遠藤康夫、谷口直之

 

シンポジウム（国際学会）

・Yaginuma Y, Yamamoto M, Tokusashi Y, Tamakawa S, Ogawa K.

Interaction of the human papillomavirus type18 E7 protein with a centromere protein

第 100 回アメリカ癌学会,Denver, 2009

 

・Yaginuma Y, Yamamoto M, Yoshie M, Tokusashi Y, Tamakawa S, Ogawa K.

Functional interaction between human papillomavirus type 18 E7 protein and centromere protein that is essential for chromosome segregation

第 98 回アメリカ癌学会, San Diego, 2007

 

・Yaginuma Y, Yamamoto M, Yoshie M, Tokusashi Y, Tamakawa S, Ogawa K.

Functional interaction of HPV18 E7 with a centromere protein which is essential for chromosome segregation

第 97 回アメリカ癌学会,Washington DC, 2006

 

．Yaginuma Y, Yamamoto M, Tamakawa A, Yoshie M, Tokusashi Y, Ogawa K.

Interaction of HPV18E7 with a centromere protein which is essential for chromosome segregation

第 96 回アメリカ癌学会, Anaheim, 2005

 

シンポジウム（国内学会）

・柳沼裕二、石川睦男、小川勝洋.

子宮癌における PTEN 遺伝子の解析と PTEN 遺伝子と相互作用する遺伝子の同定

（シンポジウム：産科婦人科領域において注目される遺伝子—その意義と 臨床応用—）

第 5 回日本産婦人科腫瘍マーカー遺伝子診断学会 東京, 2001

 

・柳沼裕二

「分子標的癌治療の進歩」CPT-11 の卵巣癌での使用経験 第 61 回北海道癌談話会秋季シンポジウム, 旭川,1996

 

 

ワークショップ（国内学会）

・Yaginuma Y, Yamamoto M, Tokusashi Y, Tamakawa S, Ogawa K.

Oncogenic HPV E7 interacts to centromere protein (CENP) and abrogates the binding of CENP toα-satellite DNA

第 67 回日本癌学会, 東京,2008

 

・柳沼裕二、田中宏樹、橋本典和、宮腰昌明、山本雅大、玉川進、吉江真澄、徳差良彦、小川勝洋.

HPV 18 型 E7 蛋白と相互作用する Centromere 蛋白の同定と結合領域の解析 第 64 回日本癌学会, 札幌,,2005

 

・柳沼裕二、山本雅大、玉川進、吉江真澄、徳差良彦、小川勝洋.

Human Papillomavirus 18 型 E7 蛋白と Centromere 蛋白との相互作用 第 63 回日本癌学会, 福岡, 2004.

 

・柳沼裕二、山本雅大、玉川進、吉江真澄、徳差良彦、小川勝洋.

Human Papillomavirus 18 型 E7 蛋白と相互作用する Centromere   protein の同定 第 62 回日本癌学会, 名古屋, 2003

 

・柳沼裕二、山本雅大、玉川進、吉江真澄、徳差良彦、小川勝洋.

子宮癌での PTEN 遺伝子の解析と Two-Hybrid System による PTEN 蛋白と相互作用する Major Vault Protein の同定

第 61 回日本癌学会, 東京, 2002

 

・柳沼裕二、安倍政彦、林博章、萬豊、清水哲哉、松井英夫、加藤志津夫、藤田昌宏、玉手健一、 山下幸紀.

卵巣腫瘍における ras 癌遺伝子産物 p21 発現およびその推移の検討

第 29 回日本臨床細胞学会、東京, 1988

 

 

一般口演(国際学会)

・Masafumi Yoshimoto, Aoi Tokuda, Yuji Yaginuma.

The PICT-1 is Required for USP7 to Effectively Stabilize p53 Protein, and Codon 389 Polymorphism is a Risk Factor for Ovarian Cancer

第１０8回アメリカ癌学会，Washington D.C., 2017

 

・Aoi Tokuda, Masafumi Yoshimoto, Yuji Yaginuma.

 USP15 inhibits HPV16 E6 degradation and catalytically inactive USP15 has reduced inhibitive activity

第１０８回アメリカ癌学会，Washington D.C., 2017

 

・Masafumi Yoshimoto, Aoi Tokuda, Yuji Yaginuma.

The codon 389 polymorphism of PICT-1 is a risk factor for human cervical cancer

第１０７回アメリカ癌学会，New Orleans, 2016

 

・Aoi Tokuda, Masafumi Yoshimoto, Yuji Yaginuma.

 Conserved region 2 of Human Papilloma Virus 18 protein E7 is required for E7 binding to centromere

  protein C

第１０７回アメリカ癌学会，New Orleans, 2016

 

・Tanaka H, Yamamoto M, Miyakoshi M, Tamakawa S, Tokusashi Y, Yaginuma Y, Ogawa K.

Rapamycin induces necrosis in mouse hepatocellular carcinomas by antiangiogenic activity, but also activates cap-independent translation of HIF-1α in hepatocellular carcinoma cells

第 100 回アメリカ癌学会, Denver, 2009

 

・Miyakoshi M, Tanaka H, Yamamoto M, Tamakawa S, Toshie M, Tokusashi Y, Yaginuma Y, Ogawa K.

IL-6 promotes cell proliferation via JAK/STAT independent pathway in mouse hepatocellular carcinoma cells

第 99 回アメリカ癌学会, Los Angeles, 2008

 

・Tanaka H, Yamamoto M, Hashimoto N, Miyakoshi M, Tamakawa S, Yoshie M, Tokusashi Y, Yaginuma Y, Ogawa K.

Reciprocal activation of PI3K/Akt signaling and HIF-1α in progression of mouse hepatocarcinogenesis

第 99 回アメリカ癌学会, Los Angeles, 2008

 

・Tamakawa S, Tokusashi Y, Yaginuma Y, Yamamoto M, Miyakoshi M, Tanaka H, Yoshie M, Ogawa K.

Possible role of neutrophins/neurotrophin receptors in the decreased nembers of hepatic stellate cells in mouse hepatic tumors

第 99 回アメリカ癌学会, Los Angeles, 2008

 

・Yaginuma Y, Yamamoto M, Yoshie M, Tokusashi Y, Tamakawa S, Ogawa K.

Human  papillomavirus  type18  E7  protein  interacts  with  the  centromere  protein  that  is  essential  for chromosome segregation

第 99 回アメリカ癌学会, Los Angeles, 2008

 

・Yamamoto M, Tanaka H, Miyakoshi M, Yoshie M, Tamakawa S, Ya ginuma Y, Ogawa K.

A novel form of cyclin D1 in proliferating mouse hepatic cells

第 98 回アメリカ癌学会, San Diego, 2007

 

・Miyakoshi M, Tanaka H, Hashimoto N, Yamamoto M, Tamakawa S, Yoshie M, Tokusashi Y, Yaginuma Y, Ogawa K.

Stat3 activation as an early change in multi-step mouse hepatocarcinogenesis

第 98 回アメリカ癌学会, San Diego, 2007

 

・Tamakawa S, Tokusashi Y, Yaginuma Y, Yamamoto M, Miyakoshi M, Hashomoto N, Tanaka H, Yoshie M, Ogawa K.

Decreased numbers of hepatic stellate cells in hepatic carcinogenesis in mice: possible role for NGF and p75NTR

第 97 回アメリカ癌学会,Washington DC, 2006

 

・Miyakoshi M, Yamamoto M, Tanaka H, Hashimoto N, Tamakawa S, Yoshie M, Tokusashi Y, Yaginuma Y, Ogawa K.

Overexpressionof cyclin D1 correlates to the activation of Stat3 during mouse hepatic carcinogenesis

第 97 回アメリカ癌学会,Washington DC, 2006

 

・Tanaka H, Yamamoto M, Hashimoto N, Miyakoshi M, Tamakawa S, Yoshie M, Tokusashi Y, Yaginuma Y, Ogawa K.

Hypoxia-independent   overexpression   of   hypoxia   inducible   factor   1 α      as   an   early   change   in

hepatocarcinogenesis in mice

第 97 回アメリカ癌学会,Washington DC, 2006

 

・Yamamoto M, Tamakawa S, Yoshie M, Yaginuma Y, Ogawa K.

Neoplastic hepatocyte growth associated with cyclin D1 redistribution from the cytoplasm to the nucleus in mouse hepatocarcinogenesis

第 97 回アメリカ癌学会,Washington DC, 2006

 

・Miyakoshi M, Yamamoto M, Tanaka H, Hashimoto N, Tamakawa S, Yoshie M, Tokusashi Y, Yaginuma Y, Ogawa K.

Localization  of  Fox01  in  the  cytoplasm  of  neoplastic  hepatocytes  during  progressioin  of  mouse  hepatic carcinogenesis

第 96 回アメリカ癌学会, Anaheim, 2005

 

・Yamamoto M, Tamakawa S,    Yoshie M, Yaginuma Y, Ogawa K.

Overexpression  of  cyclin  D1  as  an  early  change  in  mouse  hepatocarcinogenesis,  and  importance  of  its redistribution from cytoplasm to nucleus for growth of   neplastic hepatocytes

第 96 回アメリカ癌学会, Anaheim, 2005

 

・Tanaka H, Yamamoto M, Miyakoshi M, Hashimoto N, Tamakawa S, Yoshie M, Tokusashi Y, Yaginuma Y, Ogawa K.

Expression of hypoxia-inducible factor-1α(HIF-1α) in the early step of hepatic carcinogenesis

第 96 回アメリカ癌学会, Anaheim, 2005

 

・Hashimoto N, Yamamoto M, Tanaka H, Miyakoshi M, Tamakawa S, Yoshie M, Tokusashi Y, Yaginuma Y, Ogawa K.

Difference in regard to response to HGF between DRH and Donryu hepatocytes

第 96 回アメリカ癌学会, Anaheim, 2005

 

・Tamakawa S, Tokusashi Y, Yaginuma Y, Yamamoto M, Hashimoto N, Miyakoshi M, Tanaka H, Yoshie M, Ogawa K.

Decreased numbers of hepatic stellate cells in hepatic carcinogenesis in mice:possible role for NGF and p75NTR

第 96 回アメリカ癌学会, Anaheim, 2005

 

・Yuji Yaginuma, Masahiro Yamamoto, Masumi Yoshie, Yoshihiro Tokusashi, Susumu Tamakawa, Katsuhiro Ogawa

Identification of interacting proteins with HPV 18 E7 using yeast two hybrid system

第 95 回アメリカ癌学会 オーランド, 2004

 

・Satoshi Honmou, Atsuko Ozaki, Masahiro Yamamoto, Masumi Yoshie, Susumu Tamakawa, Yuji Yaginuma, Katsuhiro Ogawa

Low activation of stress activating kinases in DRH rat hepatocytes in primary culture

第 95 回アメリカ癌学会 オーランド, 2004

 

・Susumu Tamakawa, Yoshihiko Tokusashi, Yuji Yaginuma, Masahiro Yamamoto, Satoshi Honmou, Atsuko Ozaki, Masumi Yoshie, Katsuhiro Ogawa

Structural and functional characteristics of blood vessels within mouse hepatic tumors:   Comparison with normal hepatic sinusoids after lipopolysaccharide treatment

第 95 回アメリカ癌学会 オーランド, 2004

 

・Masahiro Yamamoto,Satoshi Honmou, Atsuko Ozaki, Susumu Tamakawa, Masumi Yoshie, Yuji Yaginuma, Katsuhiro Ogawa

Overexpression of cyclin D, cyclin E and p27Kip1 as eary changes in preneoplastic hepatocytes in B6C3F1 mice

第 95 回アメリカ癌学会 オーランド, 2004

 

・Yaginuma Y, Yamamoto M, Tamakawa S, Yoshie M, Tokusashi Y, Ogawa K.

Human PTEN interacts with lung   resistance-related protein (LRP) at the LRP coiled coil domain

第 94 回アメリカ癌学会, Toronto, 2003

 

・Msahiro Yamamoto, Honmo Satoshi, Keiko Asai, Emi Immura, Koji Imai, Susumu Tamakawa, Masumi Yoshie, Yuji Yaginuma, Katsuhiro Ogawa

High levels of G1 cyclins and p27kip 1 in carcinogen-altered mouse preneoplastic hepatocytes, and their early and prolonged response to the mitogenic stimuli

第 94 回アメリカ癌学会, Toronto, 2003

 

・Susumu Tamakawa,Yoshihiko Tokusashi, Yuji Yaginuma, Katsuhiro Ogawa

Reduced numbers of stellate cells in mouse hepatic tumors, but not in rat hepatic tumors

第 94 回アメリカ癌学会, Toronto, 2003

 

・Y.Yaginuma,S.Tamakawa,M.Obata, M.Yoshie, Y.Tokusashi, K.Ogawa

PTEN/MMAC1 gene alterations in human gynecologic tumors and identification of the major vault protein as a interacting protein to the PTEN/MMAC1 gene poroducts

第 93 回アメリカ癌学会, サンフランシスコ, 2002

 

・S.Tamakawa, Y.Tokusashi, Y. Ya ginuma, K.Ogawa

Reduced numbers of hepatic stellate cells in mouse hepatic tumors

第 93 回アメリカ癌学会, サンフランシスコ, 2002

 

・Yuji Yaginuma, Susumu Tamakawa, Masahiko Obata, Masumi Yoshie, Katsuhiro Ogawa

Analysis of PTEN/MMAC1 Gene and Identifying Its Interacting Genes In Human Uterine Cancers

第 92 回アメリカ癌学会, ニュ-オ-リンズ, 2001

 

・Yuji Yaginuma,T.Yamashita, T.Ishiya, A.Morizaki, Y.Katoh, H.Hayashi, and M.Ishikawa Loss of P14 ARF gene expression in human ovarian cancers but not in uterine cancers 第 91 回アメリカ癌学会, ニュ-オ-リンズ, 2000

・林博章、柳沼裕二、山下剛、斉藤裕二、森崎篤、石谷敬之、加藤育民、高橋智昭、石川睦男

Intra-operative Intravenous VS. Preoperative Oral Antibiotic Prophylaxis In¥Gynecologic Surgery.A prospective, Randomized Study

21st International Congress of Chemotherapy Birmingham,UK, 1999

 

・佐藤祐一、林 博章、青野亜美、柳沼裕二、石川睦男

Should antibiotic prophylaxis be necessary in patients   undergoing a vaginal   hysterectomy AOFOG  クアラルンプール 

 

・Y.Yaginuma, K.Kawai, Y.Saitoh, S. Kitamura, H.Kimura, H.Hayashi, K.Sengoku, M.Ishikawa

Telomerase RNA(hTR) and telomerase activity in human gynecologic tumors

第 88 回アメリカ癌学会, サンディエゴ, 1997

 

・K.Wada, H.Hayashi, Y.Yaginuma, K.Kawai, Y. Saitoh,S. Kitamura,H. Kimura, K. Sengoku, M. Ishikawa Laparoscopic treatment of selected adnexal masses for over 50 years women

6TH Annual congress of the international society for gynecologic endoscopy シンガポール, 1997

 

・Yaginuma.Y.,Nishiwaki.K.,Katayama.H., Saitoh.Y., Kawai.K., Takuma.N., Duenas.J.C., Kawamura.M., Hayashi.H., Sengoku.K.,Ishikawa.M.

Relaxation of IGF-II gene in human gynecologic tumors

第 87 回アメリカ癌学会, ワシントン DC, 1996

 

・柳沼裕二、石川睦男

Analysis of oncosuppressor gene p53, Rb and CDK4 inhibitor gene (p16) in human ovarian carcinoma

第 86 回アメリカ癌学会, フロリダ, 1995

 

・柳沼裕二、石川睦男

Analysis of oncorecessive gene (p53, Rb, APC, DCC) in human endometrial carcinoma

第 85 回アメリカ癌学会, サンフランシスコ, 1994

 

・柳沼裕二、石川睦男

Abnormal Structure and Expression of the p53 Gene in Human Ovarian Carcinoma Cell Lines

第 84 回アメリカ癌学会, フロリダ, 1993

 

 

以上、当研究室の業績の一部を掲載しました。